Identifying estrogen receptor target genes
نویسندگان
چکیده
منابع مشابه
Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray.
The estrogen receptor alpha (ERalpha) regulates gene expression by either direct binding to estrogen response elements or indirect tethering to other transcription factors on promoter targets. To identify these promoter sequences, we conducted a genome-wide screening with a novel microarray technique called ChIP-on-chip. A set of 70 candidate ERalpha loci were identified and the corresponding p...
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Estrogens and selective estrogen receptor modulators (SERMs) interact with estrogen receptor (ER) and to activate or repress gene transcription. To understand how estrogens and SERMs exert tissue-specific effects, we performed microarray analysis to determine whether ER or ER regulate different target genes in response to estrogens and SERMs. We prepared human U2OS osteosarcoma cells that are s...
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Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...
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Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...
متن کاملEstrogen receptor target gene: an evolving concept.
Estrogen receptor (ER) functions as a transcription factor to induce gene expression events sufficient for cell division and breast cancer progression. A significant body of work exists on the identification of ER gene targets and the cofactors that contribute to these transcription events, yet surprisingly little is known of the cis-regulatory elements involved. In this review, we investigate ...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2007
ISSN: 1574-7891
DOI: 10.1016/j.molonc.2007.04.001